Abstract
Treatments of pulmonary hypertension (PH) continue to evolve with approval of new
therapies. The currently FDA approved inhaled PH therapies include inhaled iloprost
for group 1 pulmonary arterial hypertension (PAH), inhaled treprostinil solution and
treprostinil dry powder inhaler for both group 1 PAH and group 3 PH associated with
interstitial lung disease (PH-ILD). Inhaled treprostinil was recently approved for
group 3 PH-ILD based on the results of INCREASE trial and the newer formulation of
treprostinil dry powder that comes with a new inhaler was recently approved for both
group 1 PAH and group 3 PH-ILD based on BREEZE study. The pipeline for inhaled PH
therapies includes several promising molecules that can enrich the current PH therapeutic
era and mitigate several systemic side effects by directly delivering the drug to
the target organ. In this review article we summarize the evidence for the currently
approved inhaled PAH/PH therapies, discuss the available inhalation devices, present
a roadmap for successful treatment strategy, and present several inhaled PAH/PH therapies
in the pipeline.
Keywords
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Article info
Publication history
Accepted:
March 6,
2023
Received:
December 7,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
