Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a dysregulated
inflammatory response that targets primarily the synovium though other extra-articular
tissues can be affected too.
1
A higher morbidity and mortality have been associated with a subset of patients who
eventually developed extra articular manifestations, such as interstitial lung disease
and rheumatoid vasculitis. Pathogenesis of RA is complex, but a combination of genetic
and environmental factors has been identified, including the presence of the “shared
epitope” HLA-DRB1 and tobacco use.To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to The American Journal of the Medical SciencesAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Rheumatoid arthritis.Nat Rev Dis Primers. 2018; 4 (Published 2018 Feb 8): 18001https://doi.org/10.1038/nrdp.2018.1
- Global epidemiology of rheumatoid arthritis.Nat Rev Rheumatol. 2022; 18: 591-602https://doi.org/10.1038/s41584-022-00827-y
- Disease profile of rheumatoid arthritis and its complications in hispanic population [published online ahead of print, 2023 Jan 5].Am J Med Sci. 2023; S0002-9629 (00529-8)https://doi.org/10.1016/j.amjms.2022.12.029
- Morbidity and mortality in patients with rheumatoid arthritis compared with an age- and sex-matched control population: A nationwide register study.J Comorb. 2019; 9 (2235042X19853484. Published 2019 Jun 3)https://doi.org/10.1177/2235042X19853484
- HLA-DRB1 and DQB typing of Hispanic American patients with rheumatoid arthritis: the “shared epitope” hypothesis may not apply.J Rheumatol. 1996; 23: 1363-1368
- HLA-DRB1 alleles associated with susceptibility or resistance to rheumatoid arthritis, articular deformities, and disability in Mexican Americans.Arthritis Rheum. 1999; 42: 1329-1338https://doi.org/10.1002/1529-0131(199907)42:7<1329::AID-ANR5>3.0.CO;2-1
- Health disparities among hispanics with rheumatoid arthritis: delay in presentation to rheumatologists contributes to later diagnosis and treatment.J Clin Rheumatol. 2020; 26: 279-284https://doi.org/10.1097/RHU.0000000000001085
- Patient's ethnicity does not influence utilization of effective therapies in rheumatoid arthritis.J Rheumatol. 2006; 33: 870-878
- Racial/ethnic differences in the use of biologic disease-modifying antirheumatic drugs among California Medicaid rheumatoid arthritis patients.Arthritis Care Res (Hoboken). 2013; 65: 299-303https://doi.org/10.1002/acr.21798
- Extraarticular manifestations of rheumatoid arthritis in a multiethnic cohort of predominantly Hispanic and Asian patients.Medicine (Baltimore). 2013; 92: 92-97https://doi.org/10.1097/MD.0b013e318289ce01
- Trust in physicians and elements of the medical interaction in patients with rheumatoid arthritis and systemic lupus erythematosus.Arthritis Rheum. 2006; 55: 385-393https://doi.org/10.1002/art.21988
- Treatment adherence in patients with rheumatoid arthritis and systemic lupus erythematosus.Clin Rheumatol. 2008; 27: 883-889https://doi.org/10.1007/s10067-007-0816-6
- Association of medication beliefs and self-efficacy with adherence in urban Hispanic and African-American rheumatoid arthritis patients.Ann Rheum Dis. 2014; 73: 317-318https://doi.org/10.1136/annrheumdis-2013-203560
- Does the “Hispanic paradox” occur in rheumatoid arthritis? Survival data from a multiethnic cohort.Arthritis Care Res (Hoboken). 2014; 66: 972-979https://doi.org/10.1002/acr.22254
- AMA Manual of style committee. updated guidance on the reporting of race and ethnicity in medical and science journals.JAMA. 2021; 326: 621-627https://doi.org/10.1001/jama.2021.13304
- Acculturation and Latino health in the United States: a review of the literature and its sociopolitical context.Annu Rev Public Health. 2005; 26: 367-397https://doi.org/10.1146/annurev.publhealth.26.021304.144615
Article info
Publication history
Published online: February 22, 2023
Accepted:
February 14,
2023
Received:
February 7,
2023
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
