Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a dysregulated inflammatory response that targets primarily the synovium though other extra-articular tissues can be affected too.
1A higher morbidity and mortality have been associated with a subset of patients who eventually developed extra articular manifestations, such as interstitial lung disease and rheumatoid vasculitis. Pathogenesis of RA is complex, but a combination of genetic and environmental factors has been identified, including the presence of the “shared epitope” HLA-DRB1 and tobacco use.
- Smolen J.S.
- Aletaha D.
- Barton A.
- et al.
Nat Rev Dis Primers. 2018; 4 (Published 2018 Feb 8): 18001https://doi.org/10.1038/nrdp.2018.1
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Published online: February 22, 2023
Accepted: February 14, 2023
Received: February 7, 2023
Publication stageIn Press Journal Pre-Proof
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