Abstract
Background
The aim of this study was to explore the difference in activated partial thromboplastin
time (APTT) levels in patients with tuberculous and non-tuberculous pleural effusion
(TPE and non-TPE) and its possible mechanism to provide a new direction for the diagnosis
of pleural effusion (PE).
Methods
A total of 61 patients diagnosed with tuberculous pleurisy with pleural effusion at
Shunde Hospital of Southern Medical University from July 2013 to September 2020 were
selected as the observation group (tuberculosis group). Another 89 patients (45 with
malignant pleural effusion (MPE) and 44 with parapneumonic pleural effusion (PPE)
composed the control group. The adenosine deaminase (ADA) level in pleural fluid and
plasma APTT level were measured in the two groups.
Results
The levels of APTT and ADA in the TPE group were significantly higher than the control
group, and were 40.03 (37.00, 42.60) (s) and 55.00 (47.00, 69.25) (U/L) for TPE, 29.50
(25.45, 34.20) (s) and 11.90 (9.15, 19.05) (U/L) for malignant pleural effusion (MPE)
and 31.35 (27.43, 35.76) (s) and 15.15 (7.40, 35.00) (U/L) for parapneumonic pleural
effusion (PPE), respectively.
Conclusions
The level of plasma APTT has certain significance in differentiating tuberculous pleural
effusion from nontuberculous pleural effusion.
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Article info
Publication history
Published online: October 21, 2022
Accepted:
September 20,
2022
Received:
October 23,
2021
Identification
Copyright
© 2023 Published by Elsevier Inc. on behalf of Southern Society for Clinical Investigation.
