Acute eosinophilic pneumonia (AEP) is an uncommon cause of respiratory failure mimicking
acute respiratory distress syndrome. AEP is characterized by fever (may not always
be present), rapid onset of respiratory symptoms (typically less than a week but up
to a month), chest infiltrate on radiologic imaging, and eosinophilic infiltration
of the pulmonary parenchyma in the absence of any known causes of pulmonary eosinophilia.
1
The eosinophilic infiltration needs to be confirmed by either a lung biopsy or bronchoalveolar
lavage (BAL), demonstrating >25% eosinophils. Although many cases are idiopathic,
a strong association has been established between AEP and smoking.
2
AEP is often seen in patients who are new smokers, resumed smoking after quitting,
or recently increased the quantity of smoking. An outbreak of electronic cigarette
and vaping associated lung injury (EVALI) occurred in the U.S. in the summer of 2019.
3
A rare subset of these patients was also reported to have suffered from AEP.
4
No study has previously compared the clinical, laboratory and radiologic parameters
in patients with AEP secondary to smoking and vaping. This manuscript aims to compare
the similarities and dissimilarities between the patients who had suffered from smoking-associated
AEP (SA-AEP) versus vaping-associated AEP (VA-AEP).Keyterms
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Article Info
Publication History
Accepted:
October 12,
2022
Received:
July 30,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Published by Elsevier Inc. on behalf of Southern Society for Clinical Investigation.
