Acute eosinophilic pneumonia (AEP) is an uncommon cause of respiratory failure mimicking
acute respiratory distress syndrome. AEP is characterized by fever (may not always
be present), rapid onset of respiratory symptoms (typically less than a week but up
to a month), chest infiltrate on radiologic imaging, and eosinophilic infiltration
of the pulmonary parenchyma in the absence of any known causes of pulmonary eosinophilia.
1
The eosinophilic infiltration needs to be confirmed by either a lung biopsy or bronchoalveolar
lavage (BAL), demonstrating >25% eosinophils. Although many cases are idiopathic,
a strong association has been established between AEP and smoking.
2
AEP is often seen in patients who are new smokers, resumed smoking after quitting,
or recently increased the quantity of smoking. An outbreak of electronic cigarette
and vaping associated lung injury (EVALI) occurred in the U.S. in the summer of 2019.
3
A rare subset of these patients was also reported to have suffered from AEP.
4
No study has previously compared the clinical, laboratory and radiologic parameters
in patients with AEP secondary to smoking and vaping. This manuscript aims to compare
the similarities and dissimilarities between the patients who had suffered from smoking-associated
AEP (SA-AEP) versus vaping-associated AEP (VA-AEP).To read this article in full you will need to make a payment
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References
- Acute eosinophilic pneumonia. causes, diagnosis, and management.Am J Respir Crit Care Med. 2018 Mar 15; 197: 728-736
- Alterations in smoking habits are associated with acute eosinophilic pneumonia.Chest. 2008 May 1; 133: 1174-1180
- Hospitalizations and deaths associated with EVALI.N Engl J Med. 2020; 382 (Apr 23): 1589-1598
- Acute eosinophilic pneumonia due to vaping-associated lung injury.J Crit Care Med. 2020; 6 (Nov 7): 259-262
- Eosinophilic pneumonia and lymphadenopathy associated with vaping and tetrahydrocannabinol use.Pediatrics. 2020 Apr; 145e20193007
- Idiopathic acute eosinophilic pneumonia: a study of 22 patients.Am J Respir Crit Care Med. 2002 Nov; 166: 1235-1239
- Acute eosinophilic pneumonia in a New York City firefighter exposed to World Trade Center dust.Am J Respir Crit Care Med. 2002; 166: 797-800
- Clinical characteristics and corticosteroid treatment of acute eosinophilic pneumonia.Eur Respir J. 2013 Feb 1; 41: 402-409
- Cigarette smoke-induced acute eosinophilic pneumonia accompanied with neutrophilia in the blood.Intern Med Tokyo Jpn. 2002 Nov; 41: 993-996
- Eosinophilic pneumonia: A review of the previous literature, causes, diagnosis, and management.Allergol Int. 2019 Oct 1; 68: 413-419
Article info
Publication history
Published online: October 17, 2022
Accepted:
October 12,
2022
Received:
July 30,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
