Case presentation
A 49-year-old woman presented with a month history of right wrist drop and thumb numbness. Electromyography/evoked potential examination indicated neurogenic damage of the right radial nerve at the spiral groove of the humerus. During exploration of the radial nerve, a tumor of 3 cm in length was attached to the nerve on the level of upper deltoid ending point (Fig. 1A). The tumor was hard, with complete capsule. The tumor was separated from the nerve and excised completely. Pathological examination indicated metastatic poorly differentiated adenocarcinoma (Fig. 1B), with the following immunohistochemistry results: CK (+) (Fig. 1C), CK7 (+) (Fig. 1D), CK18 (+) (Fig. 1E), Vimentin (+), CK20 (-), TTF-1 (-), HMB45 (-). Subsequent chest computed tomography demonstrated a lobulated nodular soft tissue density in the left upper lobe adjacent to the pleura (Fig. 1F). The patient died 1 year after diagnosis of lung cancer.
Peripheral nerve tumors are usually classified into neural sheath and nonneural sheath tumors. Peripheral neural sheath tumors include schwannomas, neurofibromas, and peripheral nerve sheath malignant tumors. Peripheral nonneural sheath tumors include granular cell tumor, ganglion cyst, lipoma, reactive lymphoid follicular hyperplasia.
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Isolated peripheral nerve metastasis is a relatively rare phenomenon, which should be considered in the context of primary malignant tumor.Source of funding
The author(s) received no financial support for the research, authorship, and/or publication of this article.
Declaration of Competing Interest
The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this manuscript.
References
- A series of 146 peripheral non-neural sheath nerve tumors: 30-year experience at Louisiana State University Health Sciences Center.J Neurosurg. 2005; 102: 256-266
- A series of 397 peripheral neural sheath tumors: 30-year experience at Louisiana State University Health Sciences Center.J Neurosurg. 2005; 102: 246-255
Article info
Publication history
Published online: September 23, 2022
Accepted:
September 19,
2022
Received:
December 19,
2021
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
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