Abstract
Background
Atelectasis and pneumonia are highly prevalent in patients under mechanical ventilation.
Studies indicate that using ventilation with an open lung concept in patients improves
recovery, decreases ventilator-related pneumonia, and decreases mortality and faster
weaning from the ventilator. Therefore, this study investigated the effect of higher
airway pressure on ventilator-associated pneumonia.
Method
This randomized clinical trial was conducted on 120 patients under mechanical ventilation.
The patients were divided into two groups based on ventilator pressure, involving
the control group (pressure level 20) and the intervention group (pressure level 30).
Demographic data, disease severity, the incidence of ventilator-associated pneumonia,
organ damage, connected to the ventilator days, length of hospitalization in ICU,
and mortality were compared between the two groups.
Results
There was no significant difference in demographic data and disease severity between
the two groups. The average Clinical Pulmonary Infection Score in the intervention
group was significantly lower than the control group (P=0.02). The intervention group's
average Sequential Organ Failure Assessment score was significantly lower than the
control group (p=0.016).
Conclusions
High-pressure levels can decrease ventilator-associated pneumonia and organ failure.
It is recommended that the study be repeated with a larger, more diverse population.
Keywords
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Article Info
Publication History
Accepted:
July 14,
2022
Received:
October 25,
2021
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Published by Elsevier Inc. on behalf of Southern Society for Clinical Investigation.
