A 38-years-old Nigerian man presented with an enlarged and vascularized conjunctival
lesion covering the corneal surface of the left eye, associated with an upper bulbar
conjunctival nodule (Fig. 1a). Magnetic resonance imaging (MRI) showed a thickened and contrast-enhancing corneal
and conjunctival-scleral lesion, mostly evident in the upper lateral surface, close
to the superior and lateral rectus muscles and lacrimal gland, which appeared enlarged
(Fig. 1b and 1c). No bone erosion of orbital walls was demonstrated on computed tomography (CT)
(Fig. 1d). After surgical evaluation, the patient underwent orbital exenteration and reconstruction
using temporalis muscle. At histopathologic examination, the diagnosis was moderately-differentiated
squamous cell carcinoma (Fig. 1e and 1f), extended to the conjunctive with infiltration of periocular striated muscles.
Immunohistochemical examination revealed the positivity for p16 (Fig. 1g) demonstrating a correlation with HPV, later confirmed by HPV-DNA PCR analysis.
Today, 5 years after surgery the patient is in well-health with no signs of recurrence.
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References
- Clinical management of squamous cell carcinoma of the conjunctiva.Am J Case Rep. 2020; 21e919751
- Human papillomavirus infection plays a role in conjunctival squamous cell carcinoma: a systematic review and meta-analysis of observational studies.Acta Ophthalmol. 2021; 99: 478-488https://doi.org/10.1111/aos.14666
- Malignant conjunctival tumors invading the orbit.Ophthalmologica. 2008; 222: 338-343
Article Info
Publication History
Published online: September 18, 2022
Accepted:
August 12,
2022
Received:
November 23,
2021
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
