Abstract
Introduction
Diffuse large B-cell lymphoma (DLBCL) patients have been reported to have cardiac
manifestations, however, arrhythmias have not been characterized in this population.
We examined the predictors of arrhythmias and assessed the impact of arrhythmias on
inpatient outcomes among DLBCL patients.
Methods
Retrospective cohort analysis was performed using the National Inpatient Sample data
collected between 2016 and 2018. Multivariable logistic and linear regression models
were used to examine the predictors of arrhythmias and inpatient outcomes among DLBCL
patients.
Results
11% of DLBCL patients had a diagnosis of arrhythmias. Patients aged 70 years or older
had 2.6 times higher odds (95% CI: 2.37–2.78) of having arrhythmias compared to patients
younger than 70 years. Females were 23% (AOR: 0.77; 95% CI: 0.71–0.83) less likely
to have a diagnosis of arrhythmias relative to their male counterparts. Compared to
non-Hispanic whites, patients who were non-Hispanic blacks (AOR: 0.69; 95% CI: 0.60–0.81),
Hispanics (AOR: 0.60; 95% CI: 0.52–0.69) or in the non-Hispanic other category (AOR:
0.80; 95% CI: 0.70–0.91) were significantly less likely to be diagnosed with arrhythmias.
Other factors that predicted arrhythmias were patient disposition and comorbidity
index. Additionally, arrhythmias were associated with higher inpatient mortality,
length of stay and hospital costs.
Conclusions
Older male patients were more likely to be diagnosed with arrhythmias while non-Hispanic
blacks and Hispanics were less likely to have arrhythmias. These findings highlight
the need for surveillance to enable early detection of arrhythmias in this population.
Key indexing terms
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References
- Integration of Cell Therapies and Bispecific Antibodies into the Treatment Pathway of Relapsed Diffuse Large B-Cell Lymphoma.SAGE Publications Sage UK, London, England2021
- Challenges and opportunities in the management of diffuse large B-cell lymphoma in older patients.Oncologist. 2021; 26: 120-132
- Diffuse large B-cell lymphoma.Pathology. 2018; 50: 74-87
- Cardiac involvement with lymphoma: a review of the literature.Clin Lymphoma Myeloma. 2008; 8: 249-252
- Primary cardiac lymphoma: B-and T-cell cases at a specialist UK centre.Ann Oncol. 2010; 21: 1041-1045
- Arrhythmia burden in patients with indolent lymphoma.Blood. 2020; 136: 6-7
- Healthcare Cost and Utilization Project (HCUP).Agency for Healthcare Research and Quality, Rockville, MD2018 (2016-)
- Atrial fibrillation in the elderly.Drugs Aging. 2013; 30: 593-601
- Prevalence and incidence of atrial fibrillation and other arrhythmias in the general older population: findings from the Swedish national study on aging and care.Gerontol Geriatr Med. 2019; 52333721419859687
- Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and risk factors in atrial fibrillation (ATRIA) study.JAMA. 2001; 285: 2370-2375
- Prevalence, age distribution, and gender of patients with atrial fibrillation. Analysis and implications.Arch Intern Med. 1995; 155: 469-473
- Epidemiology of arrhythmias and conduction disorders in older adults.Clin Geriatr Med. 2012; 28: 539-553
- Gender and cardiac arrhythmias.Tex Heart Inst J. 2001; 28: 265-275
- Gender differences in arrhythmias.Clin Cardiol. 2002; 25: 49-56
- Differences by race/ethnicity in the prevalence of clinically detected and monitor-detected atrial fibrillation: MESA.Circ Arrhythm Electrophysiol. 2020; 13e007698
- Racial and ethnic differences in the prevalence, management, and outcomes in patients with atrial fibrillation: a systematic review.Heart Rhythm. 2018; 15: 1337-1345
- Racial and ethnic differences in the management of atrial fibrillation.CJC Open. 2021; 3: S137-S148
- Trends in mortality for medicare beneficiaries treated in the emergency department from 2009 to 2016.JAMA Intern Med. 2020; 180: 80-88
- Patient and hospitalization characteristics associated with increased postacute care facility discharges from US hospitals.Med Care. 2015; 53: 492-500
- Hospital Utilization among Oldest Adults, 2008.Healthcare Cost and Utilization Project (HCUP) Statistical Briefs [Internet]. Agency for Healthcare Research and Quality (US), Rockville, MD2010 (2006 Feb–. Statistical Brief #103)
- Outcomes of patients discharged to skilled nursing facilities after acute care hospitalizations.Ann Surg. 2016; 263: 280-285
- The impact of risk factors and comorbidities on the incidence of atrial fibrillation.Mater Sociomed. 2017; 29: 231-236
- The burden of cardiac arrhythmias in sarcoidosis: a population-based inpatient analysis.Ann Transl Med. 2018; 6: 2
- Burden of comorbidities among patients with atrial fibrillation.Ther Adv Cardiovasc Dis. 2013; 7: 53-62
- The new onset of atrial arrhythmias following major noncardiothoracic surgery is associated with increased mortality.Chest. 1998; 114: 462-468
- Outcomes and mortality associated with atrial arrhythmias among patients hospitalized with COVID-19.J Cardiovasc Electrophysiol. 2020; 31: 3077-3085
- Atrial arrhythmias are associated with increased mortality in pulmonary arterial hypertension.Pulm Circ. 2018; 82045894018790316
- In-hospital mortality of patients with atrial arrhythmias: insights from the German-wide Helios hospital network of 161 502 patients and 34 025 arrhythmia-related procedures.Eur Heart J. 2018; 39: 3947-3957
- Burden of arrhythmia and electrophysiologic procedures in alcoholic cardiomyopathy hospitalizations.Int J Cardiol. 2020; 304: 61-68
Article info
Publication history
Published online: August 28, 2022
Accepted:
August 19,
2022
Received:
December 21,
2021
Identification
Copyright
© 2022 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
