Stuttering received a great deal of public attention during the run-up to the 2020 US presidential election and thereafter. A recent Viewpoint in JAMA Neurology
1even discussed the impact this neurological condition may have had on President Biden's perceived “gaffes” during debates and speeches. The etiopathogenesis of stuttering, referred to in scientific terms as Persistent Developmental Stuttering (PDS), is still under investigation, but we have learned much over the past many years. From structural alterations in the grey matter of the motor speech cortex,
- Briley PM
- Ellis C
- Jacobs MM.
The impact of stuttering—hiding in plain sight.
JAMA Neurol. 2021; 78: 646-647
2to aberrant myelination of white matter in the arcuate fasciculus,
- Watkins KE
- Smith SM
- Davis S
- Howell P
Structural and functional abnormalities of the motor system in developmental stuttering.
Brain. 2008; 131: 50-59
3to a neural networks model that shows abnormal activation characteristics of basal ganglia-thalamocortical circuits during speech,
- Cieslak M
- Ingham RJ
- Ingham JC
- Grafton ST.
Anomalous white matter morphology in adults who stutter.
J Speech Lang Hear Res. 2015; 58: 268-277
4to a recent genetic study that shows variants of the GNPTAB, GNPTG and NAGPA genes involved in lysosomal trafficking during early neural development
- Chang SE
- Guenther FH.
Involvement of the cortico-basal ganglia-thalamocortical loop in developmental stuttering.
Front Psychol. 2020; 10: 3088
5– the scientific knowledge on stuttering continues to expand.
- Frigerio-Domingues CE
- Gkalitsiou Z
- Zezinka A
- et al.
Genetic factors and therapy outcomes in persistent developmental stuttering.
J Commun Disord. 2019; 80: 11-17
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- The impact of stuttering—hiding in plain sight.JAMA Neurol. 2021; 78: 646-647
- Structural and functional abnormalities of the motor system in developmental stuttering.Brain. 2008; 131: 50-59
- Anomalous white matter morphology in adults who stutter.J Speech Lang Hear Res. 2015; 58: 268-277
- Involvement of the cortico-basal ganglia-thalamocortical loop in developmental stuttering.Front Psychol. 2020; 10: 3088
- Genetic factors and therapy outcomes in persistent developmental stuttering.J Commun Disord. 2019; 80: 11-17
Published online: May 19, 2022
Accepted: May 12, 2022
Received: September 12, 2021
© 2022 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.