Stuttering received a great deal of public attention during the run-up to the 2020
US presidential election and thereafter. A recent Viewpoint in JAMA Neurology
1
even discussed the impact this neurological condition may have had on President Biden's
perceived “gaffes” during debates and speeches. The etiopathogenesis of stuttering,
referred to in scientific terms as Persistent Developmental Stuttering (PDS), is still
under investigation, but we have learned much over the past many years. From structural
alterations in the grey matter of the motor speech cortex,
2
to aberrant myelination of white matter in the arcuate fasciculus,
3
to a neural networks model that shows abnormal activation characteristics of basal
ganglia-thalamocortical circuits during speech,
4
to a recent genetic study that shows variants of the GNPTAB, GNPTG and NAGPA genes
involved in lysosomal trafficking during early neural development
5
– the scientific knowledge on stuttering continues to expand.To read this article in full you will need to make a payment
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References
- The impact of stuttering—hiding in plain sight.JAMA Neurol. 2021; 78: 646-647
- Structural and functional abnormalities of the motor system in developmental stuttering.Brain. 2008; 131: 50-59
- Anomalous white matter morphology in adults who stutter.J Speech Lang Hear Res. 2015; 58: 268-277
- Involvement of the cortico-basal ganglia-thalamocortical loop in developmental stuttering.Front Psychol. 2020; 10: 3088
- Genetic factors and therapy outcomes in persistent developmental stuttering.J Commun Disord. 2019; 80: 11-17
Article info
Publication history
Published online: May 19, 2022
Accepted:
May 12,
2022
Received:
September 12,
2021
Identification
Copyright
© 2022 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
