A 68-year-old woman presented with an asymptomatic mass in the lung that had been detected on computed tomography (CT) during a physical screening. She had no history of hemoptysis and was otherwise well. Tumor markers were normal, including carcino-embryonic antigen (CEA), squamous cell carcinoma antigen (SCC-Ag), neuron-specific enolase (NSE) and cytokeratin 19 fragment antigen 21-1 (CYFRA21-1). Chest CT demonstrated an irregular mass with internal punctate air in the right inferior lobe, with a maximum diameter of 3.3 cm (Fig. 1A). Contrast enhancement CT showed slightly enhancement, with microvessels passing through the lesion (Fig. 1B). Thoracoscopic wedge resection of the right inferior lobe was performed, and abundant bronchus-like structures were found in the mass. Histopathology (Fig. 1C) indicated congenital cystic adenomatoid malformation (CCAM), with the following immunohistochemistry results (Fig. 1D): CK7 (+), TTF-1 (+), NapsinA (+), EMA (+), Ki-67 (10% +), P63 (+), CK5/6 (+). The patient was feeling well at 5-month follow-up.
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Published online: April 29, 2022
Accepted: April 25, 2022
Received: October 7, 2021
© 2022 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.