A 68-year-old woman presented with an asymptomatic mass in the lung that had been
detected on computed tomography (CT) during a physical screening. She had no history
of hemoptysis and was otherwise well. Tumor markers were normal, including carcino-embryonic
antigen (CEA), squamous cell carcinoma antigen (SCC-Ag), neuron-specific enolase (NSE)
and cytokeratin 19 fragment antigen 21-1 (CYFRA21-1). Chest CT demonstrated an irregular
mass with internal punctate air in the right inferior lobe, with a maximum diameter
of 3.3 cm (Fig. 1A). Contrast enhancement CT showed slightly enhancement, with microvessels passing
through the lesion (Fig. 1B). Thoracoscopic wedge resection of the right inferior lobe was performed, and abundant
bronchus-like structures were found in the mass. Histopathology (Fig. 1C) indicated congenital cystic adenomatoid malformation (CCAM), with the following
immunohistochemistry results (Fig. 1D): CK7 (+), TTF-1 (+), NapsinA (+), EMA (+), Ki-67 (10% +), P63 (+), CK5/6 (+). The
patient was feeling well at 5-month follow-up.
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References
- Congenital cystic adenomatoid malformation of the lung–Antenatal ultrasound findings and fetal-neonatal outcome. Fifteen years of experience.Fetal Diagn Ther. 2000; 15: 246-250
- Congenital cystic adenomatoid malformation - dangers of misdiagnosis–A case report.J Med Case Rep. 2017; 11: 212
- [Congenital cystic adenomatoid malformations of the lung–Diagnosis, treatment, pathophysiological hypothesis].Rev Pneumol Clin. 2013; 69: 190-197
Article info
Publication history
Published online: April 29, 2022
Accepted:
April 25,
2022
Received:
October 7,
2021
Identification
Copyright
© 2022 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
