Abstract
Background
Host biomarkers are needed to monitor the response to anti-tubercular therapy (ATT)
for ensuring effective therapy and preventing drug-resistant tuberculosis. We sought
to find the correlation between the serum levels of SAA1 and IL-1beta in response
to ATT in adult patients with pulmonary TB (PTB) or extra-pulmonary TB (EPTB).
Methods
Blood samples of 32 patients with PTB and 28 patients with EPTB were analyzed. The
blood samples were collected at baseline, two months and six months following treatment
initiation. SAA1 and IL-1beta levels were measured by enzyme linked immunosorbent
assay (ELISA).
Results
In the PTB group, the mean levels of SAA1 decreased significantly (p <0.001) after
the intensive phase (two months) and continuous phase (six months) of ATT in comparison
with the baseline value. IL-1beta values also decreased significantly (p = 0.005)
after the intensive phase (two months) compared with the baseline values. In the EPTB
group, there was a significant reduction in the mean serum level of SAA1 (p <0.001)
and IL-1beta (p = 0.001) after the intensive phase (two months) in comparison with
the baseline value, whereas the reduction at six months was not significant.
Conclusions
SAA1 and IL-1beta may be useful potential treatment-monitoring biomarkers, especially
in the intensive phase of therapy for both PTB and EPTB.
Key Indexing Terms
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Article info
Publication history
Published online: April 19, 2022
Accepted:
December 7,
2021
Received:
October 28,
2020
Identification
Copyright
© 2022 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
