Abstract
Background
The aim of the study was to evaluate the expression and clinicopathological significance
of Aquaporin-1 (AQP1) and Aquaporin-3 (AQP3) in extrahepatic cholangiocarcinoma (EHCC).
Methods
Immunostaining of AQP1 and AQP3 was performed by EnVision immunohistochemistry in
benign and malignant biliary tract tissues.
Results
The expression of AQP1 and AQP3 protein were significantly higher in EHCC tumor tissues
(P < 0.05 or P < 0.01). Adenoma and paracancerous tissues with positive AQP1 and/or AQP3 protein
expression exhibited atypical hyperplasia. AQP1 expression was positive correlated
with AQP3 expression in EHCC (P < 0.01). TNM I + II stage and radical surgery, the positive expression of AQP1 and
AQP3 In patients with well-differentiation, no invasion, no lymph metastasis, is lower
(P < 0.05 or P < 0.01). Average overall survival time of those with positive expression of AQP1
and AQP3 was significant shorter (P < 0.01). Both AQP1 and AQP3 positive expressions were proved to be an independent
prognostic factors in EHCC by cox multivariate analysis. The AUC calculated for AQP1
was 0.769 (95% confidence interval [CI]: 0.618–0.920), and that for AQP3 was 0.758
(95%CI: 0.605–0.911, while that for AQP1 and AQP3 was 0.825 (95%CI: 0.658–0.991).
Conclusions
Positive expression of AQP1 and AQP3 is closely related to the pathogenesis, severe
clinicopathological characteristics, aggressive biological behaviors, and dismal prognoses
in EHCC.
Key Indexing Terms
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Article info
Publication history
Published online: November 17, 2021
Accepted:
November 15,
2021
Received:
September 22,
2020
Identification
Copyright
© 2021 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
