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Hypertension and Hyperthyroidism: Association and Pathogenesis

Published:August 10, 2020DOI:https://doi.org/10.1016/j.amjms.2020.08.012

      Abstract

      Hypertension can cause significant morbidity and reduced life expectancy. Most patients with hypertension have primary hypertension; however, 10 to 15% of patients have secondary hypertension. Endocrine disorders explain approximately 10% of hypertension in all patients, and thyroid disorders account for approximately 1% of cases with hypertension. Hyperthyroidism can cause increased cardiac output, increased systolic blood pressures, and increased levels of renin, angiotensin, and aldosterone. Treatment of hyperthyroidism can cure hypertension in some patients. Consequently, identification of patients with secondary hypertension potentially has important benefits, and understanding secondary hypertension provides a framework for investigating the pathophysiology of hypertension. Clinicians should consider the possibility of hyperthyroidism in patients with hypertension, even in those of more advanced age.

      Keywords

      Abbreviations:

      WHO (World Health Organization), NHANES (National Health and Nutrition Examination Survey), TR (Thyroid hormone receptor)
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