ABSTRACT
Background
The study was a retrospective case-controlled study. We aimed to determine the clinical
and laboratory features of systemic lupus erythematosus (SLE) and compared the features
of autoimmune thyroid disease (AITD) with those of SLE.
Materials and Methods
The study included 38 patients with SLE with AITD (SLE-AITD) and 190 age- and gender-matched
SLE patients. The distribution of sociodemographic and clinical factors was compared
between the SLE-AITD and SLE groups using Chi-square tests for gender and t tests for others. Univariate and multivariate logistic regression models were used
to identify factors associated with the prevalence of AITD among SLE patients.
Results
In univariate analysis, malar rash, oral ulcers, serositis, anti-double-stranded DNA
antibody positivity (anti-dsDNA+), anti-Sjögren's syndrome type A antibodies (SSA),
anti-Sjögren's syndrome type B antibodies (SSB), low complement 3 (C3), and low complement
4 (C4) were significantly different between the SLE-AITD and SLE groups. There were
no significant differences among other clinical or laboratory features. In multivariate
analysis, serositis (adjusted odds ratio [AOR], 3.64; P = 0.00), anti-dsDNA+ (AOR, 0.30; P = 0.01) and low C3 (AOR, 0.30; P = 0.02) were all associated with SLE-AITD.
Conclusions
In our study, serositis was a risk factor for AITD, so we propose that AITD should
be considered in lupus patients with serositis.
Key Indexing Terms
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Article info
Publication history
Published online: July 02, 2018
Accepted:
June 25,
2018
Received:
January 16,
2018
Footnotes
☆The authors have no conflicts of interest to declare.
✯✯This article does not contain any studies with human participants or animals performed by any of the authors.
Identification
Copyright
© 2018 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
