Abstract
Background
Takayasu arteritis (TA) can involve the aortic root or cardiac valves, resulting in
hemodynamic disorders. In this study, we focused on the prevalence and clinical characteristics
of TA patients with valve regurgitation.
Materials and Methods
We retrospectively assessed the clinical data in the electronic medical records of
1,069 consecutive patients with TA admitted to Fuwai Hospital from January 1992 to
August 2017. We evaluated the valvular structure and function mainly by cardiac ultrasound.
Results
Among the 1,069 patients, 373 (34.9%) had valve regurgitation. The female to male
ratio was 4.8:1. The average age at symptom onset was 28.1 ± 10.6 years. The median
duration from symptom onset to first hospitalization was 65.9 months. Of patients
with valve involvement, 47.4% and 40.1% had a high erythrocyte sediment rate and C-reactive
protein level, respectively, at the time of echocardiography. Most patients (69.7%)
had aortic regurgitation, and nearly half had moderate to severe aortic regurgitation.
A total of 38.8% of patients had aortic valve damage, and 23.3% had involvement of
the ascending aorta. Most other valve insufficiency was mild, including mitral regurgitation
in 39.1% of patients, tricuspid regurgitation in 34.6%, and pulmonary regurgitation
in 11.8%. Valve stenosis was rare. Misdiagnosis of other cardiac diseases occurred
in 13 patients.
Conclusions
Cardiac valve insufficiency is common in Chinese TA patients. Patients should undergo
echocardiography once TA is diagnosed. In young women of reproductive age, TA should
be considered when aortic regurgitation is detected.
Key Indexing Terms
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Article info
Publication history
Published online: July 02, 2018
Accepted:
June 20,
2018
Received:
December 5,
2017
Footnotes
The authors have no financial or other conflicts of interest to disclose.
Funding: This work was funded by the National Key Research and Development Program of China (2016YFC1300100) and CAMS Innovation Fund for Medical Sciences (2016-I2M-1-002).
Identification
Copyright
© 2018 Published by Elsevier Inc. on behalf of Southern Society for Clinical Investigation.
