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Curcumin Protects Against Myocardial Ischemia-Reperfusion Injury by Activating Endothelial Nitric Oxide Synthase in Rats

Published:September 01, 2017DOI:https://doi.org/10.1016/j.amjms.2017.08.006

      Abstract

      Background

      This study aims to investigate whether or not curcumin (Cur) protects against myocardial ischemia and reperfusion (MI/R) injury via endothelial nitric oxide synthase (eNOS) activation.

      Materials and Methods

      The rats were randomly assigned to a sham group, an MI/R group, or a MI/R + Cur group. Infarct size, cell apoptosis, oxidative stress, eNOS phosphorylation expression and eNOS expression were measured.

      Results

      Cur reduced infarct size, cell apoptosis and oxidative stress compared with the MI/R group. Additionally, Cur significantly decreased eNOS phosphorylation.

      Conclusions

      Cur reduced MI/R injury via activation of eNOS. These findings suggest that Cur may be a promising therapeutic drug for MI/R injury.

      Key Indexing Terms

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