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Case Reports| Volume 329, ISSUE 3, P150-152, March 2005

Hidradenitis Suppurativa Complicated by Squamous Cell Carcinoma and Paraneoplastic Neuropathy

      ABSTRACT

      Squamous cell carcinoma is a rare complication of chronic, severe, hidradenitis suppurativa. We describe a patient with a 20-year history of extensive perineal hidradenitis suppurativa who presented with subacute muscle weakness and sensory symptoms. He was subsequently diagnosed with squamous cell carcinoma arising in the area of hidradenitis. The neurologic symptoms and signs resolved after complete excision of the tumor. This presentation is consistent with a paraneoplastic neuropathy, which has not been reported previously in patients with squamous cell carcinoma arising in patients with hidradenitis suppurativa.

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      References

        • Brown T.J.
        • Rosen T.
        • Orengo I.F.
        Hidradenitis suppurativa.
        South Med J. 1998; 91: 1107-1114
        • Kloos L.
        • Sillevis Smitt P.
        • Ang C.W.
        • et al.
        Paraneoplastic ophthalmoplegia and subacute motor axonal neuropathy associated with anti-GQ1b antibodies in a patient with malignant melanoma.
        J Neurol Neurosurg Psychiatry. 2003; 74: 507-509
        • Hara M.
        • Hunayama M.
        • Aiba S.
        • et al.
        Acrokeratosis para- neoplastica (Bazex syndrome) associated with primary cutaneous squamous cell carcinoma of the lower leg, vitiligo and alopecia areata.
        Br J Dermatol. 1995; 133: 121-124
        • Cisneros G.
        • Lara L.F.
        • Crock R.
        • et al.
        Humoral hypercalce- mia of malignancy in squamous cell carcinoma of the skin: parathyroid hormone-related protein as a cause.
        South Med J. 2001; 94: 329-331
        • Welsh D.A.
        • Powers J.S.
        Elevated parathyroid hormone-related protein and hypercalcemia in a patient with cutaneous squamous cell carcinoma complicating hidradenitis suppurativa.
        South Med J. 1993; 86: 1403-1404
        • Sparks M.K.
        • Kuhlman D.S.
        • Prieto A.
        • et al.
        Hypercalcemia in association with cutaneous squamous cell carcinoma: occurrence as a late complication of hidradenitis suppurativa.
        Arch Dermatol. 1985; 121: 243-246
        • Darnell R.B.
        • Posner J.B.
        Paraneoplastic syndromes involving the nervous system.
        N Engl J Med. 2003; 349: 1543-1554
        • Mondelli M.
        • Romano C.
        • Rossi S.
        • et al.
        Herpes zoster of the head and limbs: electroneuromyographic and clinical findings in 158 consecutive cases.
        Arch Phys Med Rehabil. 2002; 83: 1215-1221