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Case Reports| Volume 329, ISSUE 3, P141-143, March 2005

Fatal Splenic Sequestration Crisis with Multiorgan Failure in an Adult Woman with Sickle Cell-Beta+ Thalassemia

      ABSTRACT

      Acute splenic sequestration crisis is a potentially fatal condition mostly seen in children with sickle cell anemia (HbSS) up to 6 years of age. Sickle cell-beta thalassemia has been associated with development of splenic sequestration crisis in rare reports. There have also been rare reports of the development of fatal acute splenic sequestration crisis together with severe multiorgan failure in adult patients with sickle cell-beta+ thalassemia. We describe a case of fatal splenic sequestration crisis together with multiorgan failure in a 34-year-old African-American woman with sickle cell-beta+ thalassemia syndrome.

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