President’s Symposium from the 2013 Southern Regional Meeting| Volume 346, ISSUE 5, P402, November 2013

Iron Metabolism: Bedside to Bench and Back

  • Robert T. Means
    University of Kentucky College of Medicine, 138 Leader Avenue, Room 240, Lexington, KY 40506-9983
    Office of the Dean and Department of Internal Medicine, University of Kentucky College of Medicine and VA Medical Center, Lexington, Kentucky
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      One of the prerogatives of the outgoing Southern Society for Clinical Investigation President is to choose the topic and speakers for the Presidential Symposium at the annual meeting. The choice of topic for the 2013 Symposium, “Iron Metabolism: Bedside to Bench and Back,” has its genesis in a rejection letter I received some 15 years ago.

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        • Hentze M.W.
        • Rouault T.A.
        • Caughman S.W.
        • et al.
        A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron.
        Proc Natl Acad Sci U S A. 1987; 84: 6730-6734
        • Skikne B.S.
        • Flowers C.H.
        • Cook J.D.
        Serum transferrin receptor: a quantitative measure of tissue iron deficiency.
        Blood. 1990; 75: 1870-1876
        • Feder J.N.
        • Gnirke A.
        • Thomas W.
        • et al.
        A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis.
        Nat Genet. 1996; 13: 399-408
        • Park C.H.
        • Valore E.V.
        • Waring A.J.
        • et al.
        Hepcidin, a urinary antimicrobial peptide synthesized in the liver.
        J Biol Chem. 2001; 276: 7806-7810
        • Krause A.
        • Neitz S.
        • Mägert H.J.
        • et al.
        LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity.
        FEBS Lett. 2000; 480: 147-150
        • Means Jr., R.T.
        Hepcidin and iron regulation in health and disease.
        Am J Med Sci. 2013; 345: 57-60
        • Roy C.N.
        • Mak H.H.
        • Akpan I.
        • et al.
        Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation.
        Blood. 2007; 109: 4038-4044
        • Beutler E.
        Unlocking the mysteries of iron homeostasis and of the anemia of chronic disease: is hepcidin the key?.
        Blood. 2003; 102: 775