Abstract
Osteoporosis has emerged as a major health problem affecting middle-aged and older
individuals. It is characterized by a reduced bone mass and strength, resulting in
increased susceptibility to fractures. The disease is associated with several risk
factors, and increasing evidence suggests that it may be associated with oral health
conditions such as periodontal disease, reduced jaw bone density and tooth loss. Besides
the effects of osteoporosis on oral health, bisphosphonate-related osteonecrosis of
the jaws is a major concern to the dentist. Bisphosphonate-related osteonecrosis of
the jaws is a recently described adverse effect of bisphosphonate therapy. The exact
mechanisms by which these drugs cause necrosis of the jaws remain unclear, and a true
cause-and-effect relationship between osteonecrosis of the jaw and bisphosphonate
use has not yet been established. Hence, any form of invasive dentoalveolar treatment
should be performed with caution in patients taking bisphosphonates. This review discusses
current evidence on osteoporosis and its treatment implications as a risk factor in
the development of various oral diseases.
Key Indexing Terms
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Article info
Publication history
Accepted:
January 21,
2013
Received:
June 16,
2012
Footnotes
The authors have no financial or other conflicts of interest to disclose.
Identification
Copyright
© 2013 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
