Abstract
Background
Circulating insulin-like growth factor (IGF)-1 and IGF-binding protein (IGFBP)-3 levels
in the serum of Helicobacter pylori (H pylori)-infected patients were investigated.
Methods
The study subjects consisted of 54 patients with H pylori infection, and the control subjects included 27 patients without H pylori infection. There was no statistical difference in the age and sex distributions between
the study and control groups. Pretreatment serum levels of IGF-1 and IGFBP-3 were
studied in all the subjects, including the healthy controls. H pylori eradication was achieved with a triple drug regimen for 2 weeks, and 1 month after
this treatment, the serum levels of IGF-1 and IGFBP-3 were measured. The post-treatment
H pylori status by a second gastroscopy, antral histopathology and urea breath testing was
tested.
Results
The pretreatment serum levels of IGF-1 and IGFBP-3 of the study and control groups
were not found to be different (P>0.05). H pylori treatment was successful in 42 patients in whom both serum IGF-1 and IGFBP-3 levels
decreased with treatment, but the difference was only significant for the serum IGF-1
levels (P: 0.04). There was no change in the serum levels of IGF-1 and IGFBP-3 in the 27 patients
with precancereous gastric lesions before and after successful H pylori eradication.
Conclusions
No supporting evidence of a major interaction between H pylori infection itself and H pylori-associated premalignant lesions with circulating IGFBP-3 levels could be shown. Nevertheless,
successful eradication of this microorganism led to a statistically significant decrease
in serum IGF-1 levels.
Key Indexing Terms
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Article info
Publication history
Accepted:
September 19,
2012
Received:
March 3,
2012
Footnotes
Supported by funding from our local university (Zonguldak Karaelmas University Scientific Investigation Funding Committee).
Disclosure: The authors have no conflicts of interest to disclose.
Identification
Copyright
© 2012 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
