Clinical Investigation| Volume 346, ISSUE 5, P363-365, November 2013

Decreased Serum Paraoxonase Activity in Patients With Chronic Pancreatitis

  • Lan Zhang
    Department of Thoracic Surgery, First Affiliated Hospital of Liaoning Medical University, No. 2, Section 5, Renmin Street, Jinzhou, Liaoning 121001, P.R. China
    Department of Thoracic Surgery, First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning, P.R. China
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  • Benrui Lin
    Department of Thoracic Surgery, First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning, P.R. China
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      Recent evidences suggest that oxidative stress is involved in the mechanism of chronic pancreatitis (CP). Paraoxonase 1 (PON1) plays an important role as an endogenous free-radical scavenging molecule. The aim of our study is to investigate whether serum PON1 activity is associated with the presence of CP.


      A total of 186 patients with alcoholic CP and 132 healthy subjects were enrolled in this study. Serum PON1 activity was measured using paraoxon as a substrate.


      Serum PON1 activity was significantly decreased in CP patients compared with healthy subjects. Multivariable logistic regression analysis revealed that serum PON1 activity was a determinant of the presence of CP (OR=0.992, 95% CI=0.987–0.998; P=0.006).


      Decreased serum PON1 activity may be considered as a predicting marker of the presence of CP.

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