Abstract
Background
Recent evidences suggest that oxidative stress is involved in the mechanism of chronic
pancreatitis (CP). Paraoxonase 1 (PON1) plays an important role as an endogenous free-radical
scavenging molecule. The aim of our study is to investigate whether serum PON1 activity
is associated with the presence of CP.
Methods
A total of 186 patients with alcoholic CP and 132 healthy subjects were enrolled in
this study. Serum PON1 activity was measured using paraoxon as a substrate.
Results
Serum PON1 activity was significantly decreased in CP patients compared with healthy
subjects. Multivariable logistic regression analysis revealed that serum PON1 activity
was a determinant of the presence of CP (OR=0.992, 95% CI=0.987–0.998; P=0.006).
Conclusions
Decreased serum PON1 activity may be considered as a predicting marker of the presence
of CP.
Key Indexing Terms
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Article info
Publication history
Accepted:
October 9,
2012
Received:
June 14,
2012
Footnotes
Disclosure: The authors have no funding or conflicts of interest to disclose.
Identification
Copyright
© 2012 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
