Clinical Investigation| Volume 346, ISSUE 5, P353-357, November 2013

Effectiveness and Safety of Preoperative Percutaneous Transhepatic Cholangiodrainage With Bile Re-infusion in Patients With Hilar Cholangiocarcinoma: A Retrospective Controlled Study



      Extensive controversies exist over the use of preoperative biliary drainage preceding radical resection of hilar cholangiocarcinoma. This study assessed the effectiveness and safety of percutaneous transhepatic cholangiodrainage (PTCD) with bile re-infusion in the preoperative optimization of hilar cholangiocarcinoma patients.


      Eligible hilar cholangiocarcinoma patients received preoperative PTCD with bile re-infusion (treatment group, n=56) through a nasoduodenal tube for 2 weeks, and the control group (n=60) received conservative treatment alone. Operable patients were assigned to undergo either a radical or palliative resection. The outcome measures included the overall resection rate, R0 resection rate, surgical morbidity rate and 1-year and 5-year overall survival rates.


      The treatment group exhibited a significant decrease in serum bilirubin levels after PTCD with bile re-infusion. The overall resection rate was significantly higher in the treatment group than in the control group (85.5% vs. 65.0%, P<0.05), and the palliative resection rate was also significantly higher in the treatment group (53.5% vs. 35.0%, P<0.05). However, the R0 resection rate was comparable between the 2 groups (32.1% vs. 30.0%, P>0.05). The morbidity rate was significantly lower in the treatment group than in the control group (29.1% vs. 51.3%, P<0.05). One-year and 5-year survival rates were similar between the 2 groups (69.6% vs. 66.7%, P>0.05; 5.3% vs. 3.6%, P > 0.05).


      Preoperative PTCD with bile re-infusion improves the resection rate and shows a good safety profile in patients with hilar cholangiocarcinoma.

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